Polyglandular deficiency

Polyglandular deficiency syndromes can be defined as a disorder in which more then one endocrine gland is failed and unable to make enough hormones by which our body works normally.
We can divide Polyglandular deficiency in three ways-

1) Type 1- This type of Polyglandular deficiency syndrome mostly occurs in children. It results the failure of adrenal gland, gonads combined with hepatitis and thyroid gland.

2) Type 2 – This is also known as a Schmidt’s syndrome. It mainly occurs in young adults. This may cause the failure of adrenal gland and thyroid gland and it often produces the insulin dependent diabetes mellitus. In this type of disease some hair and skin changes also appear.

3) Type 3 – This also occurs in adults but in this the adrenal gland does not involves but other endocrine glands involves which can results thyroid deficiency, anemia, diabetes, pernicious anemia.

Causes of Polyglandular deficiency

An autoimmune system is the main cause of Polyglandular deficiency syndromes. In autoimmune response our body produces antibodies to its own tissues. This may affect one or more glands of our body. The demolition of one gland can lead to the damage of another gland.
Presence of tumor, insufficient blood flow, and infectious diseases is some other causes of Polyglandular deficiency syndrome.

Signs and Symptoms

Symptoms of Polyglandular deficiency syndromes are given below –

1) Hair loss
2) skin pigment changes
3) White patches on the skin

Treatment for Polyglandular deficiency

Replacement of the lost hormones is only way of treatment for Polyglandular deficiency syndromes. Proper balancing of hormones can provide a satisfactory results too the patient.