Adenomatous Polyposis Coli,Symptoms of Adenomatous Polyposis Coli,Causes of Adenomatous Polyposis Coli,Treatment for Adenomatous Polyposis Coli

Other Synonyms of adenomatous polyposis coli are:

1. Familial adenomatous polyposis or FAP.
2. Gardner syndrome.
3. Turcot syndrome.
4. Hereditary polyposis coli.
5. Familial multiple polyposis.

INTRODUCTION:-

Adenomatous polyposis coli arises in human digestive system. Adenomatous polyposis coli is an inherited condition caused by mutation (changes to genetic material ie; DNA, RNA) in genes that is inherited in an autosomal dominant (non-sex determining gene) way.

Adenomatous polyposis coli inherited condition may arise due to abuse of drugs or alcohol mainly. Adenomatous polyposis coli is rare in nature that means it develop in ratio of 1:8000-14000 (Only one person out of population of 8000, 14000).

SYMPTOMS of ADENOMATOUS POLYPOSIS COLI :

1. Formation of polyps (a mass of tissue that develop on the inside wall of hollow organ).
2. Diarrhea.
3. Abdominal pain.
4. Weight loss.
5. Bleeding from end portion of large intestine.

TYPES OR DISORDER SUBDIVISIONS of ADENOMATOUS POLYPOSIS COLI

1. ACR (Adenomatosis of the Colon and Rectum
2. Adenomatous Polyposis, Familial
3. Familial Adenomatous Colon Polyposis
4. Familial Polyposis Coli
5. Intestinal Polyposis I
6. Multiple Familial Polyposis
7. Gardner Syndrome
8. Attenuated Adenomatous Polyposis Coli (Flat Adenoma Syndrome)
9. Turcot Syndrome

DIAGNOSIS of ADENOMATOUS POLYPOSIS COLI :

1. Genetic testing by DNA linkage analysis.
2. direct nutrition testing of a person of age group of 13-20 years.

PREVENTION for ADENOMATOUS POLYPOSIS COLI:-

There are two methods of prevention of diseases:

1. By medicinal treatment.
2. by operation of the subject.

Medicinal treatment:-

The subjects will receive either 75 or 150 mg of Sulindac orally twice a day or identical-appearing placebo tablets for 48 months. The Number and size of new adenomas and side effects of therapy should be evaluated every four months for four years, and the levels of five major prostaglandins should serially measured in biopsy specimens of Normal-appearing colorectal mucosa.

Operational treatment:-

1. Ileal pouch-anal anastomosis.